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Product Categories
Recombinant Rabbit Monoclonal antibody
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Product Name
Cyclin H Rabbit mAb
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Background
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
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Alternative Names
CCNH; Cyclin-H; MO15-associated protein; p34; p37
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Immunogen
A synthetic peptide of human Cyclin H/p34
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
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Molecular Weight
Calculated MW: 38 kDa; Observed MW: 38 kDa
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Gene Name
CCNH
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Host
Rabbit
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Reactivity
Human,Mouse
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Conjugation
Unconjugated
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Application
WB,ICC/IF,IP
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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SwissProt ID
P51946
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Purification
Affinity Purified
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Clonality No.
R02-4I4
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Clonality
Monoclonal Antibody
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Isotype
IgG
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Form
Liquid
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Research Field
Cell Biology
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Gene ID
902
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Modification
Unmodified