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Product Categories
Primary antibody
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Product Name
CRTC1 Mouse mAb
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Background
MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
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Alternative Names
MECT1; TORC1; WAMTP1; FLJ14027; KIAA0616; CRTC1
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Immunogen
Purified recombinant human MECT1 / Torc1 protein fragments expressed in E.coli.
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 67 kDa; Observed MW: 78 kDa
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Clonality
Monoclonal Antibody
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Gene Name
CRTC1
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Conjugation
Unconjugated
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Isotype
IgG2b
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Host
Mouse
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Application
WB,ICC/IF,IP,FC
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Purification
Affinity Purified
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Reactivity
Human
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Form
Liquid
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Clonality No.
3D7-E5-D9
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SwissProt ID
Q6UUV9
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Research Field
Signal Transduction
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Gene ID
23373
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Modification
Unmodified