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Product Categories
Primary antibody
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Product Name
Bax (2B12) Mouse mAb
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Background
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.
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Alternative Names
Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4
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Immunogen
Purified recombinant human Bax protein fragments expressed in E.coli
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 21 kDa; Observed MW: 21 kDa
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Clonality
Monoclonal Antibody
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Gene Name
BAX
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Conjugation
Unconjugated
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Isotype
IgG2a
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Host
Mouse
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Application
WB
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Purification
Affinity Purified
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Reactivity
Human,Monkey
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Form
Liquid
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Clonality No.
2B12-G6-H6
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SwissProt ID
Q07812
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Research Field
Cell Biology
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Gene ID
581
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Modification
Unmodified