-
Product Categories
Primary antibody
-
Product Name
Phospho-ATM (Ser1981) Rabbit pAb
-
Background
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.
-
Alternative Names
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
-
Immunogen
A synthesized peptide derived from human Phospho-ATM (S1981)
-
Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50
-
Molecular Weight
Calculated MW: 351 kDa; Observed MW: 370 kDa
-
Clonality
Polyclonal Antibody
-
Gene Name
ATM
-
Conjugation
Unconjugated
-
Isotype
IgG
-
Host
Rabbit
-
Application
WB,IHC-P,ICC/IF,IP
-
Purification
Affinity Chromatography
-
Reactivity
Human
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
Form
Liquid
-
Clonality No.
-
-
SwissProt ID
Q13315
-
Research Field
Epigenetics and Nuclear Signaling
-
Gene ID
472
-
Modification
Phosphorylated