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Product Categories
Primary antibody
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Product Name
EGFR (6H11) Mouse mAb
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Background
EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation.
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Alternative Names
EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
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Immunogen
Purified recombinant human EGFR protein fragments expressed in E.coli.
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
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Molecular Weight
Calculated MW: 134 kDa; Observed MW: 175 kDa
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Clonality
Monoclonal Antibody
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Gene Name
EGFR
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Conjugation
Unconjugated
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Isotype
IgG1
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Host
Mouse
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Application
WB,ICC/IF,IP
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Purification
Affinity Purified
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Reactivity
Human,Monkey
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Form
Liquid
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Clonality No.
6H11-2D11-G3
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SwissProt ID
P00533
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Research Field
Signal Transduction
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Gene ID
1956
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Modification
Unmodified