-
Product Categories
Pathological antibody
-
Product Name
alpha Smooth Muscle Actin Mouse mAb
-
Background
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
-
Alternative Names
ACTA2; ACTSA; ACTVS; GIG46; Actin; aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; α-SMA
-
Immunogen
A synthesized peptide derived from human ACTA2
-
Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
-
Dilution Ratio
IHC: 1/100-1/200
-
Molecular Weight
-
-
Gene Name
ACTA2
-
Host
Mouse
-
Reactivity
Human
-
Conjugation
Unconjugated
-
Application
IHC-P
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
SwissProt ID
P62736
-
Purification
Affinity Purified
-
Clonality No.
1A4
-
Clonality
Monoclonal Antibody
-
Isotype
IgG
-
Form
Liquid
-
Research Field
Signal Transduction
-
Gene ID
59
-
Modification
Unmodified