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Product Categories
Pathological antibody
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Product Name
ATRX Rabbit mAb
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Background
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Alternative Names
ATP-dependent helicase ATRX; RAD54L; XH2; XNP
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Immunogen
A synthesized peptide derived from human ATRX
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
IHC: 1/100-1/200
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Molecular Weight
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Gene Name
ATRX
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Host
Rabbit
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Reactivity
Human
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Conjugation
Unconjugated
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Application
IHC-P
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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SwissProt ID
P46100
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Purification
Affinity Purified
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Clonality No.
BP6202
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Clonality
Monoclonal Antibody
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Isotype
IgG
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Form
Liquid
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Research Field
Epigenetics and Nuclear Signaling
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Gene ID
546
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Modification
Unmodified