Cat.#： R24402
Alternative Names： Gapd
Application： WB,IHC-F,IHC-P,ICC/IF,IP
Reactivity： Human,Mouse,Rat
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Doc. Data Sheet
Product Details
  • Product Categories
    Loading Control antibody
  • Product Name
    GAPDH Rabbit mAb
  • Background
    Swiss-Prot Acc.P16858.Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
  • Alternative Names
    Gapd
  • Immunogen
    Recombinant protein of human GAPDH
  • Buffer System
    50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
  • Dilution Ratio
    WB: 1/2000 IHC: 1/200 ICC/IF: 1/100 IP: 1/20
  • Molecular Weight
    Calculated MW: 36 kDa; Observed MW: 36 kDa
  • Clonality
    Monoclonal Antibody
  • Gene Name
    GAPDH
  • Conjugation
    Unconjugated
  • Isotype
    Rabbit IgG
  • Host
    Rabbit
  • Application
    WB,IHC-F,IHC-P,ICC/IF,IP
  • Purification
    Affinity Purified
  • Reactivity
    Human,Mouse,Rat
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Form
    Liquid
  • Clonality No.
    R03-5G5
  • SwissProt ID
    P16858
  • Research Field
    Neuroscience
  • Gene ID
    14433
  • Modification
    Unmodified
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