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Product Categories
Recombinant Rabbit Monoclonal antibody
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Product Name
Phospho-CBL (Ser669) Rabbit mAb
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Background
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
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Alternative Names
CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser669 of human CBL
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 100 kDa; Observed MW: 120 kDa
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Gene Name
CBL
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Host
Rabbit
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Reactivity
Human
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Conjugation
Unconjugated
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Application
WB
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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SwissProt ID
P22681
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Purification
Affinity Purified
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Clonality No.
R04-2C9
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Clonality
Monoclonal Antibody
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Isotype
IgG
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Form
Liquid
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Research Field
Cell Biology
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Gene ID
867
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Modification
Phosphorylated