CBL Rabbit mAb - Chengdu Zhengneng Biotechnology Co., Ltd

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Cat.#： R23751

Alternative Names： CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL

Application： WB,ICC/IF,IP

Reactivity： Human

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Recombinant Rabbit Monoclonal antibody
Product Name

CBL Rabbit mAb
Background

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
Alternative Names

CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL
Immunogen

A synthetic peptide of human CBL
Buffer System

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Dilution Ratio

WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Molecular Weight

Calculated MW: 100 kDa; Observed MW: 120 kDa
Gene Name

CBL
Host

Rabbit
Reactivity

Human
Conjugation

Unconjugated
Application

WB,ICC/IF,IP
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
SwissProt ID

P22681
Purification

Affinity Purified
Clonality No.

R01-9G1
Clonality

Monoclonal Antibody
Isotype

IgG
Form

Liquid
Research Field

Cell Biology
Gene ID

867
Modification

Unmodified