-
Product Categories
Primary antibody
-
Product Name
ADAM10 Rabbit mAb
-
Background
The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.
-
Alternative Names
CDw156; CD156c; ADAM10; KUZ; MADM
-
Immunogen
A synthesized peptide derived from human ADAM10
-
Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Dilution Ratio
WB: 1/500-1/1000 IP: 1/50
-
Molecular Weight
Calculated MW: 84 kDa; Observed MW: 84 kDa
-
Gene Name
ADAM10
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Conjugation
Unconjugated
-
Application
WB,IP
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
SwissProt ID
O14672
-
Purification
Affinity Chromatography
-
Clonality No.
R08-8J6
-
Clonality
Monoclonal Antibody
-
Isotype
IgG
-
Form
Liquid
-
Research Field
Cell Biology
-
Gene ID
102
-
Modification
Unmodified