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Recombinant Rabbit Monoclonal Antibodies
Cat.#:
R381197
Alternative Names:
APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5
Application:
WB,IHC-P,ICC/IF,IP
Reactivity:
Human,Mouse,Rat
Price:
USD
Quantity:
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件)
Availability:
3-4 working days
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Primary antibody
Product Name
APC Rabbit mAb
Background
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Alternative Names
APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5
Immunogen
A synthesized peptide derived from human APC
Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50
Molecular Weight
Calculated MW: 312 kDa; Observed MW: 160 kDa
Gene Name
APC
Host
Rabbit
Reactivity
Human,Mouse,Rat
Conjugation
Unconjugated
Application
WB,IHC-P,ICC/IF,IP
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
SwissProt ID
P25054
Purification
Affinity Chromatography
Clonality No.
R08-6J7
Clonality
Monoclonal Antibody
Isotype
IgG
Form
Liquid
Research Field
Cell Biology
Gene ID
324
Modification
Unmodified
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