Cat.#: R381197
Alternative Names: APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5
Application: WB,IHC-P,ICC/IF,IP
Reactivity: Human,Mouse,Rat
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Doc. Data Sheet
Product Details
  • Product Categories
    Primary antibody
  • Product Name
    APC Rabbit mAb
  • Background
    Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
  • Alternative Names
    APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5
  • Immunogen
    A synthesized peptide derived from human APC
  • Buffer System
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Dilution Ratio
    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50
  • Molecular Weight
    Calculated MW: 312 kDa; Observed MW: 160 kDa
  • Gene Name
    APC
  • Host
    Rabbit
  • Reactivity
    Human,Mouse,Rat
  • Conjugation
    Unconjugated
  • Application
    WB,IHC-P,ICC/IF,IP
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • SwissProt ID
    P25054
  • Purification
    Affinity Chromatography
  • Clonality No.
    R08-6J7
  • Clonality
    Monoclonal Antibody
  • Isotype
    IgG
  • Form
    Liquid
  • Research Field
    Cell Biology
  • Gene ID
    324
  • Modification
    Unmodified
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