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Product Categories
Recombinant Rabbit Monoclonal antibody
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Product Name
Phospho-alpha Synuclein (Ser129) Rabbit mAb
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Background
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies).
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Alternative Names
SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
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Immunogen
A synthesized peptide derived from human Phospho-alpha Synuclein (S129)
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 14 kDa; Observed MW: 18 kDa
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Gene Name
SNCA
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Host
Rabbit
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Reactivity
Human
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Conjugation
Unconjugated
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Application
WB,IHC-P,ICC/IF
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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SwissProt ID
P37840
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Purification
Affinity Chromatography
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Clonality No.
R04-7E3
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Clonality
Monoclonal Antibody
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Isotype
IgG
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Form
Liquid
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Research Field
Neuroscience
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Gene ID
6622
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Modification
Phosphorylated