Cat.#： 382804
Alternative Names： MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma
Application： WB,IHC-F,IHC-P,ICC/IF,FC,IP
Reactivity： Human,Mouse,Rat
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Quantity： - + （库存件）
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Doc. Data Sheet
Product Details
  • Product Categories
    Primary antibody
  • Product Name
    AKT Rabbit pAb
  • Background
    AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
  • Alternative Names
    MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma
  • Immunogen
    Recombinant protein of human AKT3
  • Buffer System
    50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
  • Dilution Ratio
    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100
  • Molecular Weight
    Calculated MW: 56 kDa; Observed MW: 56 kDa
  • Clonality
    Polyclonal Antibody
  • Gene Name
    AKT3
  • Conjugation
    Unconjugated
  • Isotype
    IgG
  • Host
    Rabbit
  • Application
    WB,IHC-F,IHC-P,ICC/IF,FC,IP
  • Purification
    Affinity Purified
  • Reactivity
    Human,Mouse,Rat
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Form
    Liquid
  • Clonality No.
    -
  • SwissProt ID
    Q9Y243
  • Research Field
    Signal Transduction
  • Gene ID
    10000
  • Modification
    Unmodified
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