SAFB1 (2E8) Mouse mAb - Chengdu Zhengneng Biotechnology Co., Ltd

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Cat.#： 200580

Alternative Names： SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein

Application： WB,ICC/IF,ChIP

Reactivity： Human

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Primary antibody
Product Name

SAFB1 (2E8) Mouse mAb
Background

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names

SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein
Immunogen

Purified recombinant human SAFB1 protein fragments expressed in E.coli.
Buffer System

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Dilution Ratio

WB: 1/500-1/1000 IF: 1/50-1/200 ChIP: 1/20
Molecular Weight

Calculated MW: 103 kDa; Observed MW: 130 kDa
Clonality

Monoclonal Antibody
Gene Name

SAFB
Conjugation

Unconjugated
Isotype

IgG1
Host

Mouse
Application

WB,ICC/IF,ChIP
Purification

Affinity Purified
Reactivity

Human
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Form

Liquid
Clonality No.

2E8-E2-G6
SwissProt ID

Q15424
Research Field

Epigenetics and Nuclear Signaling
Gene ID

6294
Modification

Unmodified