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Product Categories
Primary antibody
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Product Name
beta Arrestin 1 (6A1) Mouse mAb
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Background
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
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Alternative Names
ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1.
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Immunogen
Recombinant human β-Arrestin 1 protein.
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 47 kDa; Observed MW: 51 kDa
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Clonality
Monoclonal Antibody
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Gene Name
ARRB1
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Conjugation
Unconjugated
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Isotype
IgG2b
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Host
Mouse
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Application
WB
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Purification
Affinity Purified
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Reactivity
Human
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Form
Liquid
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Clonality No.
6A1-D7-C9
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SwissProt ID
P49407
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Research Field
Signal Transduction
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Gene ID
408
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Modification
Unmodified