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Product Categories
Primary antibody
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Product Name
BRAF (4E1) Mouse mAb
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Background
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations.
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Alternative Names
BRAF; BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
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Immunogen
Purified recombinant human B Raf protein fragments expressed in E.coli.
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 84 kDa; Observed MW: 87 kDa
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Clonality
Monoclonal Antibody
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Gene Name
BRAF
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Conjugation
Unconjugated
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Isotype
IgG2a
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Host
Mouse
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Application
WB
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Purification
Affinity Purified
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Reactivity
Human,Mouse
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Form
Liquid
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Clonality No.
4E1-E1-F9
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SwissProt ID
P15056
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Research Field
Cell Biology
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Gene ID
673
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Modification
Unmodified