Annexin A1 (5E4D8) Mouse mAb - Primary Antibodies - Chengdu Zhengneng Biotechnology Co., Ltd

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Cat.#： 201086-5E4

Alternative Names： ANXA1; ANX1; LPC1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35

Application： WB

Reactivity： Human,Mouse,Rat,Monkey

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Primary Antibody
Product Name

Annexin A1 (5E4D8) Mouse mAb
Background

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response . Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions . Displays Ca2+-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton .
Alternative Names

ANXA1; ANX1; LPC1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
Immunogen

Purified recombinant human Annexin A1 beta protein fragments expressed in E.coli.
Buffer System

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Dilution Ratio

WB: 1/500-1/1000
Molecular Weight

Calculated MW: 39 kDa; Observed MW: 39 kDa
Clonality

Monoclonal Antibody
Gene Name

ANXA1
Conjugation

Unconjugated
Isotype

IgG1
Host

Mouse
Application

WB
Purification

Affinity Purified
Reactivity

Human,Mouse,Rat,Monkey
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Form

Liquid
Clonality No.

5E4-D8-F12
SwissProt ID

P04083
Research Field

Signal Transduction
Gene ID

301
Modification

Unmodified