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Product Categories
Primary antibody
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Product Name
Cathepsin L Rabbit pAb
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Background
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
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Alternative Names
CTSL; CATL; CTSL1; MEP; cathepsin L
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Immunogen
Recombinant fusion protein containing a sequence of human CTSL (NP_001903.1).
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 38 kDa; Observed MW: 26,38 kDa
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Clonality
Polyclonal Antibody
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Gene Name
CTSL
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Conjugation
Unconjugated
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Isotype
IgG
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Host
Rabbit
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Application
WB,ICC/IF
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Purification
Affinity Purified
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Reactivity
Mouse,Rat
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Form
Liquid
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Clonality No.
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SwissProt ID
P07711
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Research Field
Neuroscience
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Gene ID
1514
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Modification
Unmodified