[KO] Phospho-4E BP1 (Thr46) Rabbit mAb - Chengdu Zhengneng Biotechnology Co., Ltd

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Cat.#： R22929

Alternative Names： EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

Application： WB,IHC-P,IP

Reactivity： Human,Mouse,Rat

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Product Details

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KO/KD validated
Product Name

[KO] Phospho-4E BP1 (Thr46) Rabbit mAb
Background

Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.
Alternative Names

EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Thr45 of human eIF4EBP1
Buffer System

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Dilution Ratio

WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Molecular Weight

Calculated MW: 13 kDa; Observed MW: 15-20 kDa
Gene Name

EIF4EBP1
Host

Rabbit
Reactivity

Human,Mouse,Rat
Conjugation

Unconjugated
Application

WB,IHC-P,IP
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
SwissProt ID

Q13541
Purification

Affinity Purified
Clonality No.

R03-5C7
Clonality

Monoclonal Antibody
Isotype

IgG
Form

Liquid
Research Field

Epigenetics and Nuclear Signaling
Gene ID

1978
Modification

Phosphorylated